Results
| PMID | 23252918 |
| Gene Name | PTGES |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 37 |
| Population details | 37 patients with endometrial cysts |
| Age | 32.8 +/-4.087 to 44 +/- 8.832 yrs |
| Sex | Female |
| Associated genes | COX-2, mPGES-1, and TLR4 |
| Other associated phenotypes |
Endomertiosis |
|
Am J Reprod Immunol. 2013 Mar;69(3):231-9. doi: 10.1111/aji.12056. Epub 2012 Dec Hayashi, Chuyu| Chishima, Fumihisa| Sugitani, Masahiko| Ichikawa, Go| Nakazawa-Watanabe, Teine| Sugita, Kenji| Suzuki, Manami| Nemoto, Norimichi| Yamamoto, Tatsuo Department of Obstetrics and Gynecology, Nihon University School of Medicine, Tokyo, Japan. PROBLEM: Toll-like receptors (TLRs) are innate immune receptors that mediate the pattern recognition of, and response toward, pathogens and host-derived danger signals. We reported that cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase (mPGES) mRNA were expressed in cases of endometriosis. The relationship between COX-2, mPGES-1, and TLR4 in endometriotic lesions has yet to be determined. METHOD OF STUDY: Endometriosis samples were obtained from 37 patients with endometrial cysts. Endometrial tissues were obtained from patients undergoing surgical procedures for benign gynecological conditions. COX-2, mPGES-1, and TLR4 mRNA expressions were examined by real-time quantitative reverse transcription PCR (qRT-PCR) and mPGES-1, and TLR4 protein localization was examined by immunohistochemistry. RESULTS: TLR4 proteins were mostly located to the glandular epithelium. The immunoreactivities of TLR4 and mPGES-1 from endometriosis lesions were significantly higher than those in eutopic endometrium in the proliferative phase. The expression levels of mPGES-1 mRNA in peritoneal endometriosis were higher than those in eutopic endometrium in the proliferative phase. The expression of TLR4 mRNA correlates with that of mPGES-1 mRNA and not with that of COX-2 in endometriotic lesions. CONCLUSION: Relationship between TLR4 and mPGES-1 mRNA in endometriotic lesions indicate that innate immunity may play an important role in the pathogenesis of endometriosis. Mesh Terms: Adult| Cyclooxygenase 2/genetics/*metabolism| Endometriosis/*immunology| Female| Gene Expression Regulation| Humans| Immunity, Innate| Immunohistochemistry| Intramolecular Oxidoreductases/immunology/*metabolism| Middle Aged| Ovary/*immunology| |
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